SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis
The full epigenetic repertoire governing breast cancer metastasis is not completely understood. Here, we discuss the histone methyltransferase SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) and its role in breast cancer metastasis. SETDB1 serves as an exemplar of the difficulties...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-08-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/11/8/1143 |
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Article |
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doaj-72766a8026394e94ae275ddb4764bae72020-11-25T01:17:11ZengMDPI AGCancers2072-66942019-08-01118114310.3390/cancers11081143cancers11081143SETDB-1: A Potential Epigenetic Regulator in Breast Cancer MetastasisJacob Batham0Pek Siew Lim1Sudha Rao2Melanie Swan Memorial Translational Centre, Faculty of Sci-Tech, University of Canberra, Bruce ACT 2617, AustraliaMelanie Swan Memorial Translational Centre, Faculty of Sci-Tech, University of Canberra, Bruce ACT 2617, AustraliaMelanie Swan Memorial Translational Centre, Faculty of Sci-Tech, University of Canberra, Bruce ACT 2617, AustraliaThe full epigenetic repertoire governing breast cancer metastasis is not completely understood. Here, we discuss the histone methyltransferase SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) and its role in breast cancer metastasis. SETDB1 serves as an exemplar of the difficulties faced when developing therapies that not only specifically target cancer cells but also the more elusive and aggressive stem cells that contribute to metastasis via epithelial-to-mesenchymal transition and confer resistance to therapies.https://www.mdpi.com/2072-6694/11/8/1143breast cancercancer stem cellstherapyresistancerecurrenceSETDB1epigenetics |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jacob Batham Pek Siew Lim Sudha Rao |
| spellingShingle |
Jacob Batham Pek Siew Lim Sudha Rao SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis Cancers breast cancer cancer stem cells therapy resistance recurrence SETDB1 epigenetics |
| author_facet |
Jacob Batham Pek Siew Lim Sudha Rao |
| author_sort |
Jacob Batham |
| title |
SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis |
| title_short |
SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis |
| title_full |
SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis |
| title_fullStr |
SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis |
| title_full_unstemmed |
SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis |
| title_sort |
setdb-1: a potential epigenetic regulator in breast cancer metastasis |
| publisher |
MDPI AG |
| series |
Cancers |
| issn |
2072-6694 |
| publishDate |
2019-08-01 |
| description |
The full epigenetic repertoire governing breast cancer metastasis is not completely understood. Here, we discuss the histone methyltransferase SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) and its role in breast cancer metastasis. SETDB1 serves as an exemplar of the difficulties faced when developing therapies that not only specifically target cancer cells but also the more elusive and aggressive stem cells that contribute to metastasis via epithelial-to-mesenchymal transition and confer resistance to therapies. |
| topic |
breast cancer cancer stem cells therapy resistance recurrence SETDB1 epigenetics |
| url |
https://www.mdpi.com/2072-6694/11/8/1143 |
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