Timp1 Promotes Cell Survival by Activating the PDK1 Signaling Pathway in Melanoma

Timp1 Promotes Cell Survival by Activating the PDK1 Signaling Pathway in Melanoma

High TIMP1 expression is associated with poor prognosis in melanoma, where it can bind to CD63 and β1 integrin, inducing PI3-kinase pathway and cell survival. Phosphatidylinositol (3,4,5)-trisphosphate (PIP3), generated under phosphatidylinositol-3-kinase (PI3K) activation, enables the recruitment a...

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Bibliographic Details
Main Authors: Mariana Toricelli, Fabiana H. M. Melo, Aline Hunger, Daniela Zanatta, Bryan E. Strauss, Miriam G. Jasiulionis
Format: Article
Language:English
Published: MDPI AG 2017-04-01
Series:Cancers
Subjects:
Timp1
anoikis resistance
PI3K pathway
PDK1
PKC
melanoma
Online Access:http://www.mdpi.com/2072-6694/9/4/37

Internet

http://www.mdpi.com/2072-6694/9/4/37

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