Modulation of Global Transcriptional Regulatory Networks as a Strategy for Increasing Kanamycin Resistance of the Translational Elongation Factor-G Mutants in Escherichia coli

Modulation of Global Transcriptional Regulatory Networks as a Strategy for Increasing Kanamycin Resistance of the Translational Elongation Factor-G Mutants in Escherichia coli

Evolve and resequence experiments have provided us a tool to understand bacterial adaptation to antibiotics. In our previous work, we used short-term evolution to isolate mutants resistant to the ribosome targeting antibiotic kanamycin, and reported that Escherichia coli develops low cost resistance...

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Bibliographic Details
Main Authors: Aalap Mogre, Reshma T. Veetil, Aswin Sai Narain Seshasayee
Format: Article
Language:English
Published: Oxford University Press 2017-12-01
Series:G3: Genes, Genomes, Genetics
Subjects:
antibiotic resistance
aminoglycosides
kanamycin
transcription factors
gene regulatory networks
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.117.300284

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http://g3journal.org/lookup/doi/10.1534/g3.117.300284

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