Opioid and GABAB receptors differentially couple to an adenylyl cyclase/protein kinase A downstream effector after chronic morphine treatment.

Opioid and GABAB receptors differentially couple to an adenylyl cyclase/protein kinase A downstream effector after chronic morphine treatment.

Opioids are intensely addictive, and cessation of their chronic use is associated with a highly aversive withdrawal syndrome. A cellular hallmark of withdrawal is an opioid sensitive protein kinase A-dependent increase in GABA transporter-1 (GAT-1) currents in periaqueductal gray (PAG) neurons. Elev...

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Bibliographic Details
Main Author: Elena Elizabeth Bagley
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Pharmacology
Subjects:
Morphine
Periaqueductal Gray
opioid
withdrawal
GABAB receptor
GAT-1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00148/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00148/full

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