Synthesis, Molecular Docking Studies, In Vitro Antimicrobial and Antifungal Activities of Novel Dipeptide Derivatives Based on N-(2-(2-Hydrazinyl-2-oxoethylamino)-2-oxoethyl)-Nicotinamide

Synthesis, Molecular Docking Studies, In Vitro Antimicrobial and Antifungal Activities of Novel Dipeptide Derivatives Based on N-(2-(2-Hydrazinyl-2-oxoethylamino)-2-oxoethyl)-Nicotinamide

A series of linear dipeptide derivatives (4–10) were prepared and evaluated as antimicrobial agents via the synthesis of N-(2-(2-hydrazinyl-2-oxoethylamino)-2-oxoethyl) nicotinamide (4). Compound 4 was reacted with 4-chlorobenzaldehyde or 4-hydroxybenzaldehyde, to give the hydrazones 5 and 6, respec...

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Bibliographic Details
Main Authors: Gaber Moustafa, Hemat Khalaf, Ahmed Naglah, Asma Al-Wasidi, Nawal Al-Jafshar, Hassan Awad
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Molecules
Subjects:
nicotinoyl chloride
amino acids
linear dipeptides
antimicrobial activity
molecular docking studies
Online Access:http://www.mdpi.com/1420-3049/23/4/761

Internet

http://www.mdpi.com/1420-3049/23/4/761

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