Metabolome Changes during In Vivo Red Cell Aging Reveal Disruption of Key Metabolic Pathways

Summary: Understanding the mechanisms for cellular aging is a fundamental question in biology. Normal red blood cells (RBCs) survive for approximately 100 days, and their survival is likely limited by functional decline secondary to cumulative damage to cell constituents, which may be reflected in a...

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Bibliographic Details
Main Authors: Neema Jamshidi, Xiuling Xu, Katharina von Löhneysen, Katrin Soldau, Rob P. Mohney, Edward D. Karoly, Mike Scott, Jeffrey S. Friedman
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220308221