Chronic OVA allergen challenged Siglec-F deficient mice have increased mucus, remodeling, and epithelial Siglec-F ligands which are up-regulated by IL-4 and IL-13

Chronic OVA allergen challenged Siglec-F deficient mice have increased mucus, remodeling, and epithelial Siglec-F ligands which are up-regulated by IL-4 and IL-13

<p>Abstract</p> <p>Background</p> <p>In this study we examined the role of Siglec-F, a receptor highly expressed on eosinophils, in contributing to mucus expression, airway remodeling, and Siglec-F ligand expression utilizing Siglec-F deficient mice exposed to chronic a...

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Bibliographic Details
Main Authors: Doherty Taylor A, Dayan Shanna, Miller Marina, Rosenthal Peter, Pham Alexa, Song Dae Jae, Cho Jae Youn, Varki Ajit, Broide David H
Format: Article
Language:English
Published: BMC 2010-11-01
Series:Respiratory Research
Online Access:http://respiratory-research.com/content/11/1/154

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http://respiratory-research.com/content/11/1/154

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