Plasma levels of PCSK9 and phenotypic variability in familial hypercholesterolemia

The extent of hypercholesterolemia varies considerably in patients with familial hypercholesterolemia (FH). We hypothesized that the variability of the FH phenotype might be partly explained by variation in proprotein convertase subtilisin kexin type 9 (PCSK9) activity. Individuals between 18 and 53...

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Bibliographic Details
Main Authors: R. Huijgen, S.W. Fouchier, M. Denoun, B.A. Hutten, M.N. Vissers, G. Lambert, J.J.P. Kastelein
Format: Article
Language:English
Published: Elsevier 2012-05-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520392282