Non-enzymatic functions of retroviral integrase：next target for the novel anti-HIV drug development.
Integrase (IN) is a retroviral enzyme that catalyzes the insertion of viral DNA into host chromosomal DNA, which is necessary for efficient viral replication. The crystal structure of prototype foamy virus IN bound to cognate viral DNA ends, a complex referred to as the intasome, has recently been r...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2011-10-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2011.00210/full |