A T-cell engager-armed oncolytic vaccinia virus to target the tumor stroma

A T-cell engager-armed oncolytic vaccinia virus to target the tumor stroma

Aim: Cancer-associated fibroblasts (CAFs) are the key cellular components of the tumor stroma. CAFs express fibroblast activation protein (FAP) and FAP-targeted immunotherapies have shown potent antitumor effects in preclinical mouse studies, highlighting their central role in tumorigenesis. However...

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Bibliographic Details
Main Authors: Feng Yu, Bangxing Hong, Xiao-Tong Song
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2017-01-01
Series:Cancer Translational Medicine
Subjects:
Cancer-associated fibroblast
fibroblast activation protein
oncolytic virus
T-cell engager
tumor stroma
Online Access:http://www.cancertm.com/article.asp?issn=2395-3977;year=2017;volume=3;issue=4;spage=122;epage=132;aulast=Yu

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http://www.cancertm.com/article.asp?issn=2395-3977;year=2017;volume=3;issue=4;spage=122;epage=132;aulast=Yu

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