Systemic Immune Modulation in Gliomas: Prognostic Value of Plasma IL-6, YKL-40, and Genetic Variation in YKL-40

Systemic Immune Modulation in Gliomas: Prognostic Value of Plasma IL-6, YKL-40, and Genetic Variation in YKL-40

Background: Complex local and systemic immune dysfunction in glioblastoma (GBM) may affect survival. Interleukin (IL)-6 and YKL-40 are pleiotropic biomarkers present in the tumor microenvironment and involved in immune regulation. We therefore analyzed plasma IL-6, YKL-40, and genetic variation in Y...

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Bibliographic Details
Main Authors: Camilla Bjørnbak Holst, Ib Jarle Christensen, Jane Skjøth-Rasmussen, Petra Hamerlik, Hans Skovgaard Poulsen, Julia Sidenius Johansen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Oncology
Subjects:
biomarkers
glioblastoma
glioma
IL-6
immune dysfunction
YKL-40
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00478/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.00478/full

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