Synchronization of Intracellular Ca2+ Release in Multicellular Cardiac Preparations

In myocardial tissue, Ca2+ release from the sarcoplasmic reticulum (SR) that occurs via the ryanodine receptor (RyR2) channel complex. Ca2+ release through RyR2 can be either stimulated by an action potential (AP) or spontaneous. The latter is often associated with triggered afterdepolarizations, wh...

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Bibliographic Details
Main Authors: Jessica L. Slabaugh, Lucia Brunello, Mohammad T. Elnakish, Nima Milani-Nejad, Sandor Gyorke, Paul M. L. Janssen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Physiology
Subjects:
rat
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00968/full