A peek into cancer-associated fibroblasts: origins, functions and translational impact

In malignant tumors, cancer cells adapt to grow within their host tissue. As a cancer progresses, an accompanying host stromal response evolves within and around the nascent tumor. Among the host stromal constituents associated with the tumor are cancer-associated fibroblasts, a highly abundant and...

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Bibliographic Details
Main Authors: Valerie S. LeBleu, Raghu Kalluri
Format: Article
Language:English
Published: The Company of Biologists 2018-04-01
Series:Disease Models & Mechanisms
Subjects:
Online Access:http://dmm.biologists.org/content/11/4/dmm029447