Structural Variations in Articular Cartilage Matrix Are Associated with Early-Onset Osteoarthritis in the Spondyloepiphyseal Dysplasia Congenita (Sedc) Mouse

Structural Variations in Articular Cartilage Matrix Are Associated with Early-Onset Osteoarthritis in the Spondyloepiphyseal Dysplasia Congenita (Sedc) Mouse

Heterozgyous spondyloepiphyseal dysplasia congenita (sedc/+) mice expressing a missense mutation in col2a1 exhibit a normal skeletal morphology but early-onset osteoarthritis (OA). We have recently examined knee articular cartilage obtained from homozygous (sedc/sedc) mice, which express a Stickler-...

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Bibliographic Details
Main Authors: Robert E. Seegmiller, Christopher R. Cunningham, David L. Kooyman, Nicholas B. Heimann, Melissa Baker, Shaela A. Avery, Jason Adams, David W. Macdonald, Ryan S. Squires
Format: Article
Language:English
Published: MDPI AG 2013-08-01
Series:International Journal of Molecular Sciences
Subjects:
spondyloepiphyseal dysplasia congenita (sedc)
proteoglycan
animal model of osteoarthritis
Col2a1
type II collagen
articular cartilage
extracellular matrix
Online Access:http://www.mdpi.com/1422-0067/14/8/16515

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http://www.mdpi.com/1422-0067/14/8/16515

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