Increased uptake of doxorubicin by cells undergoing heat stress does not explain its synergistic cytotoxicity with hyperthermia

Increased uptake of doxorubicin by cells undergoing heat stress does not explain its synergistic cytotoxicity with hyperthermia

Purpose: A proposed mechanism for the enhanced effectiveness of hyperthermia and doxorubicin (Dox) combinations is increased intracellular Dox concentrations resulting from heat-induced cell stress. The purpose of this study was to determine whether specific varied Dox and heat combinations produce...

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Bibliographic Details
Main Authors: Anirudh Sharma, Sanem Özayral, Julia S. Caserto, Rosemarie ten Cate, Nicole M. Anders, James D. Barnett, Sri Kamal Kandala, Elizabeth Henderson, Jacqueline Stewart, Eleni Liapi, Michelle A. Rudek, Nicolaas A.P. Franken, Arlene L. Oei, Preethi Korangath, Fred Bunz, Robert Ivkov
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:International Journal of Hyperthermia
Subjects:
hyperthermia
chemotherapy
doxorubicin
colorectal cancer
thermal dose
Online Access:http://dx.doi.org/10.1080/02656736.2019.1631494

Internet

http://dx.doi.org/10.1080/02656736.2019.1631494

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