The Leptomeninges Produce Prostaglandin D2 Involved in Sleep Regulation in Mice

The Leptomeninges Produce Prostaglandin D2 Involved in Sleep Regulation in Mice

Injection of nanomolar amounts of prostaglandin D2 (PGD2) into the rat brain has dose and time-dependent somnogenic effects, and the PGD2-induced sleep is indistinguishable from physiologic sleep. Sleep-inducing PGD2 is produced in the brain by lipocalin-type PGD2 synthase (LPGDS). Three potential i...

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Bibliographic Details
Main Authors: Yoan Cherasse, Kosuke Aritake, Yo Oishi, Mahesh K. Kaushik, Mustafa Korkutata, Yoshihiro Urade
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
prostaglandin D2
leptomeninges
lipocalin-type prostaglandin D synthase
sleep
adeno-associated virus (AAV)
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00357/full

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https://www.frontiersin.org/article/10.3389/fncel.2018.00357/full

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