Binding of hepatic lipase to heparin: identification of specific heparin-binding residues in two distinct positive charge clusters

Binding of hepatic lipase to heparin: identification of specific heparin-binding residues in two distinct positive charge clusters

The interaction of hepatic lipase (HL) with heparan sulfate is critical to the function of this enzyme. The primary amino acid sequence of HL was compared to that of lipoprotein lipase (LPL), a related enzyme that possesses several putative heparin-binding domains. Of the three putative heparin-bind...

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Bibliographic Details
Main Authors: Rebecca A. Sendak, Darlene E. Berryman, Gabrielle Gellman, Kristan Melford, Andre Bensadoun
Format: Article
Language:English
Published: Elsevier 2000-02-01
Series:Journal of Lipid Research
Subjects:
hepatic lipase
heparin binding domains
lipoprotein lipase
heparin sulfate proteoglycans
Chinese hamster ovary cells
heparin-Sepharose chromatography
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520320605

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http://www.sciencedirect.com/science/article/pii/S0022227520320605

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