Increased Level of Vascular Endothelial Growth Factors by 4-hexylresorcinol is Mediated by Transforming Growth Factor-β1 and Accelerates Capillary Regeneration in the Burns in Diabetic Animals

Increased Level of Vascular Endothelial Growth Factors by 4-hexylresorcinol is Mediated by Transforming Growth Factor-β1 and Accelerates Capillary Regeneration in the Burns in Diabetic Animals

4-Hexyl resorcinol (4HR) is an organic compound and has been used in skin care application. 4HR is an M2-type macrophage activator and elevates vascular endothelial growth factor (VEGF) expression via the hypoxia-inducible factor (HIF)-independent pathway. As endothelial cells are important in wound...

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Bibliographic Details
Main Authors: Dae-Won Kim, You-Young Jo, Umberto Garagiola, Je-Yong Choi, Yei-Jin Kang, Ji-Hyeon Oh, Seong-Gon Kim
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
4-hexylresorcinol
HUVEC
diabetes mellitus
TGF-β1
angiogenesis
Online Access:https://www.mdpi.com/1422-0067/21/10/3473

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https://www.mdpi.com/1422-0067/21/10/3473

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