In vivo delivery of adenoviral vector containing interleukin-17 receptor a reduces cardiac remodeling and improves myocardial function in viral myocarditis leading to dilated cardiomyopathy.

In vivo delivery of adenoviral vector containing interleukin-17 receptor a reduces cardiac remodeling and improves myocardial function in viral myocarditis leading to dilated cardiomyopathy.

Th17 cells have been implicated in the pathogenesis of myocarditis. Interleukin (IL)-17A produced by Th17 cells is dispensable for viral myocarditis but essential for the progression to dilated cardiomyopathy (DCM). This study investigated whether the adenoviral transfer of the IL-17 receptor A redu...

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Bibliographic Details
Main Authors: Yuquan Xie, Minghui Li, Xinggang Wang, Xian Zhang, Tianqing Peng, Yingzhen Yang, Yunzeng Zou, Junbo Ge, Haozhu Chen, Ruizhen Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3748008?pdf=render

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http://europepmc.org/articles/PMC3748008?pdf=render

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