Self-Amplifying Pestivirus Replicon RNA Encoding Influenza Virus Nucleoprotein and Hemagglutinin Promote Humoral and Cellular Immune Responses in Pigs

Self-Amplifying Pestivirus Replicon RNA Encoding Influenza Virus Nucleoprotein and Hemagglutinin Promote Humoral and Cellular Immune Responses in Pigs

Self-amplifying replicon RNA (RepRNA) promotes expansion of mRNA templates encoding genes of interest through their replicative nature, thus providing increased antigen payloads. RepRNA derived from the non-cytopathogenic classical swine fever virus (CSFV) targets monocytes and dendritic cells (DCs)...

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Bibliographic Details
Main Authors: Thomas Démoulins, Nicolas Ruggli, Markus Gerber, Lisa J. Thomann-Harwood, Thomas Ebensen, Kai Schulze, Carlos A. Guzmán, Kenneth C. McCullough
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
self-amplifying replicon RNA
virus replicon particle
polyplexes
influenza vaccines
humoral and cellular immune response
c-di-AMP adjuvant
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.622385/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.622385/full

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