Doxorubicin-Induced Translocation of mtDNA into the Nuclear Genome of Human Lymphocytes Detected Using a Molecular-Cytogenetic Approach

Doxorubicin-Induced Translocation of mtDNA into the Nuclear Genome of Human Lymphocytes Detected Using a Molecular-Cytogenetic Approach

Translocation of mtDNA in the nuclear genome is an ongoing process that contributes to the development of pathological conditions in humans. However, the causal factors of this biological phenomenon in human cells are poorly studied. Here we analyzed mtDNA insertions in the nuclear genome of human l...

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Bibliographic Details
Main Authors: Tigran Harutyunyan, Ahmed Al-Rikabi, Anzhela Sargsyan, Galina Hovhannisyan, Rouben Aroutiounian, Thomas Liehr
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
CBMN assay
doxorubicin
FISH
mtDNA insertion in nuclei
micronuclei
Online Access:https://www.mdpi.com/1422-0067/21/20/7690

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https://www.mdpi.com/1422-0067/21/20/7690

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