Receptor-mediated endocytosis of α-galactosidase A in human podocytes in Fabry disease.

Receptor-mediated endocytosis of α-galactosidase A in human podocytes in Fabry disease.

Injury to the glomerular podocyte is a key mechanism in human glomerular disease and podocyte repair is an important therapeutic target. In Fabry disease, podocyte injury is caused by the intracellular accumulation of globotriaosylceramide. This study identifies in the human podocyte three endocytic...

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Bibliographic Details
Main Authors: Thaneas Prabakaran, Rikke Nielsen, Jakob V Larsen, Søren S Sørensen, Ulla Feldt-Rasmussen, Moin A Saleem, Claus M Petersen, Pierre J Verroust, Erik I Christensen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3176300?pdf=render

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http://europepmc.org/articles/PMC3176300?pdf=render

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