Ubiquitin E3 ligase Ring1b/Rnf2 of polycomb repressive complex 1 contributes to stable maintenance of mouse embryonic stem cells.

Ubiquitin E3 ligase Ring1b/Rnf2 of polycomb repressive complex 1 contributes to stable maintenance of mouse embryonic stem cells.

Polycomb repressive complex 1 (PRC1) core member Ring1b/Rnf2, with ubiquitin E3 ligase activity towards histone H2A at lysine 119, is essential for early embryogenesis. To obtain more insight into the role of Ring1b in early development, we studied its function in mouse embryonic stem (ES) cells.We...

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Bibliographic Details
Main Authors: Petra van der Stoop, Erwin A Boutsma, Danielle Hulsman, Sonja Noback, Mike Heimerikx, Ron M Kerkhoven, J Willem Voncken, Lodewyk F A Wessels, Maarten van Lohuizen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2375055?pdf=render

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http://europepmc.org/articles/PMC2375055?pdf=render

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