Anthrax toxins inhibit neutrophil signaling pathways in brain endothelium and contribute to the pathogenesis of meningitis.

Anthrax toxins inhibit neutrophil signaling pathways in brain endothelium and contribute to the pathogenesis of meningitis.

Anthrax meningitis is the main neurological complication of systemic infection with Bacillus anthracis approaching 100% mortality. The presence of bacilli in brain autopsies indicates that vegetative bacteria are able to breach the blood-brain barrier (BBB). The BBB represents not only a physical ba...

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Bibliographic Details
Main Authors: Nina M van Sorge, Celia M Ebrahimi, Shauna M McGillivray, Darin Quach, Mojgan Sabet, Donald G Guiney, Kelly S Doran
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2493037?pdf=render

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http://europepmc.org/articles/PMC2493037?pdf=render

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