Bioactive Brominated Oxindole Alkaloids from the Red Sea Sponge <i>Callyspongia siphonella</i>

Bioactive Brominated Oxindole Alkaloids from the Red Sea Sponge <i>Callyspongia siphonella</i>

In the present study, LC-HRESIMS-assisted dereplication along with bioactivity-guided isolation led to targeting two brominated oxindole alkaloids (compounds <b>1</b> and <b>2</b>) which probably play a key role in the previously reported antibacterial, antibiofilm, and cytot...

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Bibliographic Details
Main Authors: Seham S. El-Hawary, Ahmed M. Sayed, Rabab Mohammed, Hossam M. Hassan, Mostafa E. Rateb, Elham Amin, Tarek A. Mohammed, Mohamed El-Mesery, Abdullatif Bin Muhsinah, Abdulrhman Alsayari, Harald Wajant, Mohamed A. Anany, Usama Ramadan Abdelmohsen
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Marine Drugs
Subjects:
<i>Callyspongia siphonella</i>
LC-HRESIMS
metabolomic profiling
oxindole alkaloids
tisindoline
antibacterial
antibiofilm
antitrypanosomal
anticancer
Online Access:https://www.mdpi.com/1660-3397/17/8/465

Internet

https://www.mdpi.com/1660-3397/17/8/465

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