Structural evidence for Scc4-dependent localization of cohesin loading

Structural evidence for Scc4-dependent localization of cohesin loading

The cohesin ring holds newly replicated sister chromatids together until their separation at anaphase. Initiation of sister chromatid cohesion depends on a separate complex, Scc2NIPBL/Scc4Mau2 (Scc2/4), which loads cohesin onto DNA and determines its localization across the genome. Proper cohesin lo...

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Bibliographic Details
Main Authors: Stephen M Hinshaw, Vasso Makrantoni, Alastair Kerr, Adèle L Marston, Stephen C Harrison
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-06-01
Series:eLife
Subjects:
centromere
sister chromatid cohesion
cohesin loading
Online Access:https://elifesciences.org/articles/06057

Internet

https://elifesciences.org/articles/06057

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