Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage

Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage

The relative contribution of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)4 and ADAMTS5 to aggrecan degradation under oncostatin M (OSM) stimulation, the role of the ancillary domains of the aggrecanases on their ability to cleave within the chondroitin sulfate (CS)-2 regio...

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Bibliographic Details
Main Authors: M Durigova, L Troeberg, H Nagase, PJ Roughley, JS Mort
Format: Article
Language:English
Published: AO Research Institute Davos 2011-01-01
Series:European Cells & Materials
Subjects:
Cartilage catabolism
proteoglycan aggregate
ADAMTS
hyaluronidase
oncostatin M
Online Access:http://www.ecmjournal.org/journal/papers/vol021/pdf/v021a03.pdf

Internet

http://www.ecmjournal.org/journal/papers/vol021/pdf/v021a03.pdf

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