Piperlongumine, a piper alkaloid targets Ras/PI3K/Akt/mTOR signaling axis to inhibit tumor cell growth and proliferation in DMH/DSS induced experimental colon cancer

Piperlongumine, a piper alkaloid targets Ras/PI3K/Akt/mTOR signaling axis to inhibit tumor cell growth and proliferation in DMH/DSS induced experimental colon cancer

Colorectal cancer (CRC) is the most common carcinoma of the digestive tract. The slow growing nature of CRC offers a great opportunity for prevention strategies. The concept of chemoprevention of colorectal cancer using plant derived natural products is gaining substantial attention because it is an...

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Bibliographic Details
Main Authors: Sandeep Kumar, Navneet Agnihotri
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Piperlongumine
Colorectal cancer
Apoptosis
Cell proliferation
PI3K/Akt/mTOR signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218342999

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http://www.sciencedirect.com/science/article/pii/S0753332218342999

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