PTWAS: investigating tissue-relevant causal molecular mechanisms of complex traits using probabilistic TWAS analysis

PTWAS: investigating tissue-relevant causal molecular mechanisms of complex traits using probabilistic TWAS analysis

Abstract We propose a new computational framework, probabilistic transcriptome-wide association study (PTWAS), to investigate causal relationships between gene expressions and complex traits. PTWAS applies the established principles from instrumental variables analysis and takes advantage of probabi...

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Bibliographic Details
Main Authors: Yuhua Zhang, Corbin Quick, Ketian Yu, Alvaro Barbeira, The GTEx Consortium, Francesca Luca, Roger Pique-Regi, Hae Kyung Im, Xiaoquan Wen
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Genome Biology
Subjects:
TWAS
eQTLs
GWAS
Causal inference
Genetic association
Instrumental variable
Online Access:http://link.springer.com/article/10.1186/s13059-020-02026-y

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