CORE GREML for estimating covariance between random effects in linear mixed models for complex trait analyses

by Xuan Zhou, Hae Kyung Im, S. Hong Lee
Published 2020-08-01

A scalable unified framework of total and allele-specific counts for cis-QTL, fine-mapping, and prediction

by Yanyu Liang, François Aguet, Alvaro N. Barbeira, Kristin Ardlie, Hae Kyung Im
Published 2021-03-01

Trans-ethnic predicted expression genome-wide association analysis identifies a gene for estrogen receptor-negative breast cancer.

by Guimin Gao, Brandon L Pierce, Olufunmilayo I Olopade, Hae Kyung Im, Dezheng Huo
Published 2017-09-01

Integrating predicted transcriptome from multiple tissues improves association detection.

by Alvaro N Barbeira, Milton Pividori, Jiamao Zheng, Heather E Wheeler, Dan L Nicolae, Hae Kyung Im
Published 2019-01-01

Mixed effects modeling of proliferation rates in cell-based models: consequence for pharmacogenomics and cancer.

by Hae Kyung Im, Eric R Gamazon, Amy L Stark, R Stephanie Huang, Nancy J Cox, M Eileen Dolan
Published 2012-02-01

Exprtarget: an integrative approach to predicting human microRNA targets.

by Eric R Gamazon, Hae-Kyung Im, Shiwei Duan, Yves A Lussier, Nancy J Cox, M Eileen Dolan, Wei Zhang
Published 2010-10-01

PTWAS: investigating tissue-relevant causal molecular mechanisms of complex traits using probabilistic TWAS analysis

by Yuhua Zhang, Corbin Quick, Ketian Yu, Alvaro Barbeira, The GTEx Consortium, Francesca Luca, Roger Pique-Regi, Hae Kyung Im, Xiaoquan Wen
Published 2020-09-01

Survey of the Heritability and Sparse Architecture of Gene Expression Traits across Human Tissues.

by Heather E Wheeler, Kaanan P Shah, Jonathon Brenner, Tzintzuni Garcia, Keston Aquino-Michaels, GTEx Consortium, Nancy J Cox, Dan L Nicolae, Hae Kyung Im
Published 2016-11-01

Genetic architecture of gene expression traits across diverse populations.

by Lauren S Mogil, Angela Andaleon, Alexa Badalamenti, Scott P Dickinson, Xiuqing Guo, Jerome I Rotter, W Craig Johnson, Hae Kyung Im, Yongmei Liu, Heather E Wheeler
Published 2018-08-01

Transcriptome prediction performance across machine learning models and diverse ancestries

by Paul C. Okoro, Ryan Schubert, Xiuqing Guo, W. Craig Johnson, Jerome I. Rotter, Ina Hoeschele, Yongmei Liu, Hae Kyung Im, Amy Luke, Lara R. Dugas, Heather E. Wheeler
Published 2021-04-01

sn-spMF: matrix factorization informs tissue-specific genetic regulation of gene expression

by Yuan He, Surya B. Chhetri, Marios Arvanitis, Kaushik Srinivasan, François Aguet, Kristin G. Ardlie, Alvaro N. Barbeira, Rodrigo Bonazzola, Hae Kyung Im, GTEx Consortium, Christopher D. Brown, Alexis Battle
Published 2020-09-01

Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

by Alvaro N. Barbeira, Scott P. Dickinson, Rodrigo Bonazzola, Jiamao Zheng, Heather E. Wheeler, Jason M. Torres, Eric S. Torstenson, Kaanan P. Shah, Tzintzuni Garcia, Todd L. Edwards, Eli A. Stahl, Laura M. Huckins, GTEx Consortium, Dan L. Nicolae, Nancy J. Cox, Hae Kyung Im
Published 2018-05-01

Impact of admixture and ancestry on eQTL analysis and GWAS colocalization in GTEx

by Nicole R. Gay, Michael Gloudemans, Margaret L. Antonio, Nathan S. Abell, Brunilda Balliu, YoSon Park, Alicia R. Martin, Shaila Musharoff, Abhiram S. Rao, François Aguet, Alvaro N. Barbeira, Rodrigo Bonazzola, Farhad Hormozdiari, GTEx Consortium, Kristin G. Ardlie, Christopher D. Brown, Hae Kyung Im, Tuuli Lappalainen, Xiaoquan Wen, Stephen B. Montgomery
Published 2020-09-01

Exploiting the GTEx resources to decipher the mechanisms at GWAS loci

by Alvaro N. Barbeira, Rodrigo Bonazzola, Eric R. Gamazon, Yanyu Liang, YoSon Park, Sarah Kim-Hellmuth, Gao Wang, Zhuoxun Jiang, Dan Zhou, Farhad Hormozdiari, Boxiang Liu, Abhiram Rao, Andrew R. Hamel, Milton D. Pividori, François Aguet, GTEx GWAS Working Group, Lisa Bastarache, Daniel M. Jordan, Marie Verbanck, Ron Do, GTEx Consortium, Matthew Stephens, Kristin Ardlie, Mark McCarthy, Stephen B. Montgomery, Ayellet V. Segrè, Christopher D. Brown, Tuuli Lappalainen, Xiaoquan Wen, Hae Kyung Im
Published 2021-01-01

Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts

by Laura M. Huckins, Chris Chatzinakos, Michael S. Breen, Jakob Hartmann, Torsten Klengel, Ana C. da Silva Almeida, Amanda Dobbyn, Kiran Girdhar, Gabriel E. Hoffman, Claudia Klengel, Mark W. Logue, Adriana Lori, Adam X. Maihofer, Filomene G. Morrison, Hoang T. Nguyen, Yongjin Park, Douglas Ruderfer, Laura G. Sloofman, Sanne J.H. van Rooij, Dewleen G. Baker, Chia-Yen Chen, Nancy Cox, Laramie E. Duncan, Mark A. Geyer, Stephen J. Glatt, Hae Kyung Im, Victoria B. Risbrough, Jordan W. Smoller, Dan J. Stein, Rachel Yehuda, Israel Liberzon, Karestan C. Koenen, Tanja Jovanovic, Manolis Kellis, Mark W. Miller, Silviu-Alin Bacanu, Caroline M. Nievergelt, Joseph D. Buxbaum, Pamela Sklar, Kerry J. Ressler, Eli A. Stahl, Nikolaos P. Daskalakis
Published 2020-06-01

A Trans-Ethnic Genome-Wide Association Study of Uterine Fibroids

by Todd L. Edwards, Todd L. Edwards, Todd L. Edwards, Ayush Giri, Ayush Giri, Ayush Giri, Jacklyn N. Hellwege, Jacklyn N. Hellwege, Jacklyn N. Hellwege, Katherine E. Hartmann, Katherine E. Hartmann, Elizabeth A. Stewart, Janina M. Jeff, Michael J. Bray, Sarah A. Pendergrass, Eric S. Torstenson, Eric S. Torstenson, Eric S. Torstenson, Jacob M. Keaton, Jacob M. Keaton, Jacob M. Keaton, Sarah H. Jones, Sarah H. Jones, Radhika P. Gogoi, Helena Kuivaniemi, Helena Kuivaniemi, Kathryn L. Jackson, Abel N. Kho, Iftikhar J. Kullo, Catherine A. McCarty, Hae Kyung Im, Jennifer A. Pacheco, Jyotishman Pathak, Marc S. Williams, Gerard Tromp, Gerard Tromp, Eimear E. Kenny, Eimear E. Kenny, Peggy L. Peissig, Joshua C. Denny, Dan M. Roden, Digna R. Velez Edwards, Digna R. Velez Edwards, Digna R. Velez Edwards
Published 2019-06-01

Pleiotropy-guided transcriptome imputation from normal and tumor tissues identifies candidate susceptibility genes for breast and ovarian cancer

by Siddhartha P. Kar, Daniel P.C. Considine, Jonathan P. Tyrer, Jasmine T. Plummer, Stephanie Chen, Felipe S. Dezem, Alvaro N. Barbeira, Padma S. Rajagopal, Will T. Rosenow, Fernando Moreno, Clara Bodelon, Jenny Chang-Claude, Georgia Chenevix-Trench, Anna deFazio, Thilo Dörk, Arif B. Ekici, Ailith Ewing, George Fountzilas, Ellen L. Goode, Mikael Hartman, Florian Heitz, Peter Hillemanns, Estrid Høgdall, Claus K. Høgdall, Tomasz Huzarski, Allan Jensen, Beth Y. Karlan, Elza Khusnutdinova, Lambertus A. Kiemeney, Susanne K. Kjaer, Rüdiger Klapdor, Martin Köbel, Jingmei Li, Clemens Liebrich, Taymaa May, Håkan Olsson, Jennifer B. Permuth, Paolo Peterlongo, Paolo Radice, Susan J. Ramus, Marjorie J. Riggan, Harvey A. Risch, Emmanouil Saloustros, Jacques Simard, Lukasz M. Szafron, Linda Titus, Cheryl L. Thompson, Robert A. Vierkant, Stacey J. Winham, Wei Zheng, Jennifer A. Doherty, Andrew Berchuck, Kate Lawrenson, Hae Kyung Im, Ani W. Manichaikul, Paul D.P. Pharoah, Simon A. Gayther, Joellen M. Schildkraut
Published 2021-07-01

Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.

by Anubha Mahajan, Xueling Sim, Hui Jin Ng, Alisa Manning, Manuel A Rivas, Heather M Highland, Adam E Locke, Niels Grarup, Hae Kyung Im, Pablo Cingolani, Jason Flannick, Pierre Fontanillas, Christian Fuchsberger, Kyle J Gaulton, Tanya M Teslovich, N William Rayner, Neil R Robertson, Nicola L Beer, Jana K Rundle, Jette Bork-Jensen, Claes Ladenvall, Christine Blancher, David Buck, Gemma Buck, Noël P Burtt, Stacey Gabriel, Anette P Gjesing, Christopher J Groves, Mette Hollensted, Jeroen R Huyghe, Anne U Jackson, Goo Jun, Johanne Marie Justesen, Massimo Mangino, Jacquelyn Murphy, Matt Neville, Robert Onofrio, Kerrin S Small, Heather M Stringham, Ann-Christine Syvänen, Joseph Trakalo, Goncalo Abecasis, Graeme I Bell, John Blangero, Nancy J Cox, Ravindranath Duggirala, Craig L Hanis, Mark Seielstad, James G Wilson, Cramer Christensen, Ivan Brandslund, Rainer Rauramaa, Gabriela L Surdulescu, Alex S F Doney, Lars Lannfelt, Allan Linneberg, Bo Isomaa, Tiinamaija Tuomi, Marit E Jørgensen, Torben Jørgensen, Johanna Kuusisto, Matti Uusitupa, Veikko Salomaa, Timothy D Spector, Andrew D Morris, Colin N A Palmer, Francis S Collins, Karen L Mohlke, Richard N Bergman, Erik Ingelsson, Lars Lind, Jaakko Tuomilehto, Torben Hansen, Richard M Watanabe, Inga Prokopenko, Josee Dupuis, Fredrik Karpe, Leif Groop, Markku Laakso, Oluf Pedersen, Jose C Florez, Andrew P Morris, David Altshuler, James B Meigs, Michael Boehnke, Mark I McCarthy, Cecilia M Lindgren, Anna L Gloyn, T2D-GENES consortium and GoT2D consortium
Published 2015-01-01

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function

by Annah B. Wyss, Tamar Sofer, Mi Kyeong Lee, Natalie Terzikhan, Jennifer N. Nguyen, Lies Lahousse, Jeanne C. Latourelle, Albert Vernon Smith, Traci M. Bartz, Mary F. Feitosa, Wei Gao, Tarunveer S. Ahluwalia, Wenbo Tang, Christopher Oldmeadow, Qing Duan, Kim de Jong, Mary K. Wojczynski, Xin-Qun Wang, Raymond Noordam, Fernando Pires Hartwig, Victoria E. Jackson, Tianyuan Wang, Ma’en Obeidat, Brian D. Hobbs, Tianxiao Huan, Hongsheng Gui, Margaret M. Parker, Donglei Hu, Lauren S. Mogil, Gleb Kichaev, Jianping Jin, Mariaelisa Graff, Tamara B. Harris, Ravi Kalhan, Susan R. Heckbert, Lavinia Paternoster, Kristin M. Burkart, Yongmei Liu, Elizabeth G. Holliday, James G. Wilson, Judith M. Vonk, Jason L. Sanders, R. Graham Barr, Renée de Mutsert, Ana Maria Baptista Menezes, Hieab H. H. Adams, Maarten van den Berge, Roby Joehanes, Albert M. Levin, Jennifer Liberto, Lenore J. Launer, Alanna C. Morrison, Colleen M. Sitlani, Juan C. Celedón, Stephen B. Kritchevsky, Rodney J. Scott, Kaare Christensen, Jerome I. Rotter, Tobias N. Bonten, Fernando César Wehrmeister, Yohan Bossé, Shujie Xiao, Sam Oh, Nora Franceschini, Jennifer A. Brody, Robert C. Kaplan, Kurt Lohman, Mark McEvoy, Michael A. Province, Frits R. Rosendaal, Kent D. Taylor, David C. Nickle, L. Keoki Williams, Esteban G. Burchard, Heather E. Wheeler, Don D. Sin, Vilmundur Gudnason, Kari E. North, Myriam Fornage, Bruce M. Psaty, Richard H. Myers, George O’Connor, Torben Hansen, Cathy C. Laurie, Patricia A. Cassano, Joohon Sung, Woo Jin Kim, John R. Attia, Leslie Lange, H. Marike Boezen, Bharat Thyagarajan, Stephen S. Rich, Dennis O. Mook-Kanamori, Bernardo Lessa Horta, André G. Uitterlinden, Hae Kyung Im, Michael H. Cho, Guy G. Brusselle, Sina A. Gharib, Josée Dupuis, Ani Manichaikul, Stephanie J. London
Published 2018-07-01