Combining losartan with radiotherapy increases tumor control and inhibits lung metastases from a HER2/neu-positive orthotopic breast cancer model

Combining losartan with radiotherapy increases tumor control and inhibits lung metastases from a HER2/neu-positive orthotopic breast cancer model

Abstract Background Patients with metastatic HER2/neu-positive (HER2/neu +) breast cancer (BC) often experience treatment resistance, disease recurrences and metastases. Thus, new approaches for improving the treatment of HER2/neu + BC to prevent metastatic dissemination are urgently needed. Our pre...

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Bibliographic Details
Main Authors: Wende Li, Sen Li, Ivy X. Chen, Yujiao Liu, Rakesh R. Ramjiawan, Chi-Ho Leung, Leo E. Gerweck, Dai Fukumura, Jay S. Loeffler, Rakesh K. Jain, Dan G. Duda, Peigen Huang
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Radiation Oncology
Subjects:
Radiotherapy
Losartan
Angiotensin receptor blocker
Metastatic breast cancer
Mouse model
Online Access:https://doi.org/10.1186/s13014-021-01775-9

Internet

https://doi.org/10.1186/s13014-021-01775-9

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