Inhibition of Murine Cytomegalovirus Infection in Animals by RNase P-Associated External Guide Sequences

Inhibition of Murine Cytomegalovirus Infection in Animals by RNase P-Associated External Guide Sequences

External guide sequence (EGS) RNAs are associated with ribonuclease P (RNase P), a tRNA processing enzyme, and represent promising agents for gene-targeting applications as they can direct RNase-P-mediated cleavage of a target mRNA. Using murine cytomegalovirus (MCMV) as a model system, we examined...

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Bibliographic Details
Main Authors: Wei Li, Jingxue Sheng, Mengqiong Xu, Gia-Phong Vu, Zhu Yang, Yujun Liu, Xu Sun, Phong Trang, Sangwei Lu, Fenyong Liu
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
antisense
gene therapy
herpesvirus
RNase P
gene targeting
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117302688

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http://www.sciencedirect.com/science/article/pii/S2162253117302688

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