Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors.

Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors.

CD47 is an immune checkpoint molecule that downregulates key aspects of both the innate and adaptive anti-tumor immune response via its counter receptor SIRPα, and it is expressed at high levels in a wide variety of tumor types. This has led to the development of biologics that inhibit SIRPα engagem...

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Bibliographic Details
Main Authors: Thomas W Miller, Joshua D Amason, Elsa D Garcin, Laurence Lamy, Patricia K Dranchak, Ryan Macarthur, John Braisted, Jeffrey S Rubin, Teresa L Burgess, Catherine L Farrell, David D Roberts, James Inglese
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0218897

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https://doi.org/10.1371/journal.pone.0218897

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