Comparison of gE/gI- and TK/gE/gI-Gene-Deleted Pseudorabies Virus Vaccines Mediated by CRISPR/Cas9 and Cre/Lox Systems

Comparison of gE/gI- and TK/gE/gI-Gene-Deleted Pseudorabies Virus Vaccines Mediated by CRISPR/Cas9 and Cre/Lox Systems

Pseudorabies (PR), caused by pseudorabies virus (PRV), is an acute and febrile infectious disease in swine. To eradicate PR, a more efficacious vaccine needs to be developed. Here, the gE/gI- and TK/gE/gI-gene-deleted recombinant PRV (rGXΔgE/gI and rGXΔTK/gE/gI) are constructed through CRISPR/Cas9 a...

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Bibliographic Details
Main Authors: Jianglong Li, Kui Fang, Zhenxiang Rong, Xinxin Li, Xujiao Ren, Hui Ma, Huanchun Chen, Xiangmin Li, Ping Qian
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Viruses
Subjects:
CRISPR/Cas9
Cre/Lox
pseudorabies virus
vaccine
Online Access:https://www.mdpi.com/1999-4915/12/4/369

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https://www.mdpi.com/1999-4915/12/4/369

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