Comparison of gE/gI- and TK/gE/gI-Gene-Deleted Pseudorabies Virus Vaccines Mediated by CRISPR/Cas9 and Cre/Lox Systems
Pseudorabies (PR), caused by pseudorabies virus (PRV), is an acute and febrile infectious disease in swine. To eradicate PR, a more efficacious vaccine needs to be developed. Here, the gE/gI- and TK/gE/gI-gene-deleted recombinant PRV (rGXΔgE/gI and rGXΔTK/gE/gI) are constructed through CRISPR/Cas9 a...
Main Authors: | Jianglong Li, Kui Fang, Zhenxiang Rong, Xinxin Li, Xujiao Ren, Hui Ma, Huanchun Chen, Xiangmin Li, Ping Qian |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-03-01
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Series: | Viruses |
Subjects: | |
Online Access: | https://www.mdpi.com/1999-4915/12/4/369 |
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