Transcriptional Suppression of Diabetic Nephropathy with Novel Gene Silencer Pyrrole-Imidazole Polyamides Preventing USF1 Binding to the TGF-β1 Promoter

Transcriptional Suppression of Diabetic Nephropathy with Novel Gene Silencer Pyrrole-Imidazole Polyamides Preventing USF1 Binding to the TGF-β1 Promoter

Upstream stimulatory factor 1 (USF1) is a transcription factor that is increased in high-glucose conditions and activates the transforming growth factor (TGF)-β1 promoter. We examined the effects of synthetic pyrrole-imidazole (PI) polyamides in preventing USF1 binding on the TGF-β1 promoter in Wist...

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Bibliographic Details
Main Authors: Makiyo Okamura, Noboru Fukuda, Shu Horikoshi, Hiroki Kobayashi, Akiko Tsunemi, Yurie Akiya, Morito Endo, Taro Matsumoto, Masanori Abe
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
diabetic nephropathy
osteopontin
pyrrole-imidazole polyamide
rat
TGF-β1
USF1
Online Access:https://www.mdpi.com/1422-0067/22/9/4741

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https://www.mdpi.com/1422-0067/22/9/4741

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