Neuromelanin, neurotransmitter status and brainstem location determine the differential vulnerability of catecholaminergic neurons to mitochondrial DNA deletions

Neuromelanin, neurotransmitter status and brainstem location determine the differential vulnerability of catecholaminergic neurons to mitochondrial DNA deletions

<p>Abstract</p> <p>Background</p> <p>Deletions of the mitochondrial DNA (mtDNA) accumulate to high levels in dopaminergic neurons of the substantia nigra pars compacta (SNc) in normal aging and in patients with Parkinson's disease (PD). Human nigral neurons charact...

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Bibliographic Details
Main Authors: Elstner Matthias, Müller Sarina K, Leidolt Lars, Laub Christoph, Krieg Lena, Schlaudraff Falk, Liss Birgit, Morris Chris, Turnbull Douglass M, Masliah Eliezer, Prokisch Holger, Klopstock Thomas, Bender Andreas
Format: Article
Language:English
Published: BMC 2011-12-01
Series:Molecular Brain
Subjects:
Parkinson disease
aging
neurodegeneration
catecholaminergic neurons
mitochondrial DNA
single neuron analysis
laser-microdissection
Online Access:http://www.molecularbrain.com/content/4/1/43

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http://www.molecularbrain.com/content/4/1/43

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