Cell-Based in Vitro Blood–Brain Barrier Model Can Rapidly Evaluate Nanoparticles’ Brain Permeability in Association with Particle Size and Surface Modification

Cell-Based in Vitro Blood–Brain Barrier Model Can Rapidly Evaluate Nanoparticles’ Brain Permeability in Association with Particle Size and Surface Modification

The possibility of nanoparticle (NP) uptake to the human central nervous system is a major concern. Recent reports showed that in animal models, nanoparticles (NPs) passed through the blood–brain barrier (BBB). For the safe use of NPs, it is imperative to evaluate the permeability of NPs through the...

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Bibliographic Details
Main Authors: Sanshiro Hanada, Kouki Fujioka, Yuriko Inoue, Fumihide Kanaya, Yoshinobu Manome, Kenji Yamamoto
Format: Article
Language:English
Published: MDPI AG 2014-01-01
Series:International Journal of Molecular Sciences
Subjects:
blood–brain barrier
nanoparticles
cell-based assay
permeability coefficient
Online Access:http://www.mdpi.com/1422-0067/15/2/1812

Internet

http://www.mdpi.com/1422-0067/15/2/1812

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