UV Differentially Induces Oxidative Stress, DNA Damage and Apoptosis in BCR-ABL1-Positive Cells Sensitive and Resistant to Imatinib

UV Differentially Induces Oxidative Stress, DNA Damage and Apoptosis in BCR-ABL1-Positive Cells Sensitive and Resistant to Imatinib

Chronic myeloid leukemia (CML) cells express the active BCR-ABL1 protein, which has been targeted by imatinib in CML therapy, but resistance to this drug is an emerging problem. BCR-ABL1 induces endogenous oxidative stress promoting genomic instability and imatinib resistance. In the present work, w...

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Bibliographic Details
Main Authors: Ewelina Synowiec, Grazyna Hoser, Katarzyna Wojcik, Elzbieta Pawlowska, Tomasz Skorski, Janusz Błasiak
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:International Journal of Molecular Sciences
Subjects:
BCR-ABL1
imatinib resistance
DNA damage
apoptosis
reactive oxygen species
Online Access:http://www.mdpi.com/1422-0067/16/8/18111

Internet

http://www.mdpi.com/1422-0067/16/8/18111

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