Efficient Induction of Cytotoxic T Cells by Viral Vector Vaccination Requires STING-Dependent DC Functions

Efficient Induction of Cytotoxic T Cells by Viral Vector Vaccination Requires STING-Dependent DC Functions

Modified Vaccinia virus Ankara (MVA) is an attenuated strain of vaccinia virus and currently under investigation as a promising vaccine vector against infectious diseases and cancer. MVA acquired mutations in host range and immunomodulatory genes, rendering the virus deficient for replication in mos...

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Bibliographic Details
Main Authors: Cornelia Barnowski, Gregor Ciupka, Ronny Tao, Lei Jin, Dirk H. Busch, Sha Tao, Ingo Drexler
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
viral vector vaccine
dendritic cells
STING
modified vaccinia virus Ankara MVA
cytotoxic T cells
type I interferon
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01458/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01458/full

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