Progranulin facilitates conversion and function of regulatory T cells under inflammatory conditions.

Progranulin facilitates conversion and function of regulatory T cells under inflammatory conditions.

The progranulin (PGRN) is known to protect regulatory T cells (Tregs) from a negative regulation by TNF-α, and its levels are elevated in various kinds of autoimmune diseases. Whether PGRN directly regulates the conversion of CD4+CD25-T cells into Foxp3-expressing regulatory T cells (iTreg), and whe...

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Bibliographic Details
Main Authors: Fanhua Wei, Yuying Zhang, Weiming Zhao, Xiuping Yu, Chuan-Ju Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4230946?pdf=render

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http://europepmc.org/articles/PMC4230946?pdf=render

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