Inhibition of Nipah virus infection in vivo: targeting an early stage of paramyxovirus fusion activation during viral entry.

Inhibition of Nipah virus infection in vivo: targeting an early stage of paramyxovirus fusion activation during viral entry.

In the paramyxovirus cell entry process, receptor binding triggers conformational changes in the fusion protein (F) leading to viral and cellular membrane fusion. Peptides derived from C-terminal heptad repeat (HRC) regions in F have been shown to inhibit fusion by preventing formation of the fusoge...

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Bibliographic Details
Main Authors: Matteo Porotto, Barry Rockx, Christine C Yokoyama, Aparna Talekar, Ilaria Devito, Laura M Palermo, Jie Liu, Riccardo Cortese, Min Lu, Heinz Feldmann, Antonello Pessi, Anne Moscona
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-10-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2965769?pdf=render

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http://europepmc.org/articles/PMC2965769?pdf=render

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