Neutralizing Anti-Hemagglutinin Monoclonal Antibodies Induced by Gene-Based Transfer Have Prophylactic and Therapeutic Effects on Influenza Virus Infection

Neutralizing Anti-Hemagglutinin Monoclonal Antibodies Induced by Gene-Based Transfer Have Prophylactic and Therapeutic Effects on Influenza Virus Infection

Hemagglutinin (HA) of influenza virus is a major target for vaccines. HA initiates the internalization of the virus into the host cell by binding to host sialic acid receptors; therefore, inhibition of HA can significantly prevent influenza virus infection. However, the high diversity of HA permits...

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Bibliographic Details
Main Authors: Tatsuya Yamazaki, Joe Chiba, Sachiko Akashi-Takamura
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Vaccines
Subjects:
hemagglutinin
antibody drug
passive immune-prophylaxis
passive immune-therapy
antibody-gene
gene therapy
plasmid vector
adeno-associated virus (AAV) vector
electro-transfer
hydrodynamic injection
Online Access:http://www.mdpi.com/2076-393X/6/3/35

Internet

http://www.mdpi.com/2076-393X/6/3/35

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