Thymoquinone Is a Multitarget Single Epidrug That Inhibits the UHRF1 Protein Complex

Thymoquinone Is a Multitarget Single Epidrug That Inhibits the UHRF1 Protein Complex

Silencing of tumor suppressor genes (TSGs) through epigenetic mechanisms, mainly via abnormal promoter DNA methylation, is considered a main mechanism of tumorigenesis. The abnormal DNA methylation profiles are transmitted from the cancer mother cell to the daughter cells through the involvement of...

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Bibliographic Details
Main Authors: Omeima Abdullah, Ziad Omran, Salman Hosawi, Ali Hamiche, Christian Bronner, Mahmoud Alhosin
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Genes
Subjects:
thymoquinone
UHRF1
epigenetic drug
cancer
tumor suppressor gene
Online Access:https://www.mdpi.com/2073-4425/12/5/622

Internet

https://www.mdpi.com/2073-4425/12/5/622

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