Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimer’s disease

Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimer’s disease

Abstract Background Elevated blood homocysteine levels, termed hyperhomocysteinemia (HHcy), is a prevalent risk factor for Alzheimer’s disease (AD) in elderly populations. While dietary supplementation of B-vitamins is a generally effective method to lower homocysteine levels, there is little if any...

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Bibliographic Details
Main Authors: David J. Braun, Edgardo Dimayuga, Josh M. Morganti, Linda J. Van Eldik
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer’s disease
Amyloid
Homocysteine
Hyperhomocysteinemia
Microglia
Neuroinflammation
Online Access:http://link.springer.com/article/10.1186/s12974-020-01938-7

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http://link.springer.com/article/10.1186/s12974-020-01938-7

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