Valproic Acid Reduces Vasospasm through Modulation of Akt Phosphorylation and Attenuates Neuronal Apoptosis in Subarachnoid Hemorrhage Rats

Valproic Acid Reduces Vasospasm through Modulation of Akt Phosphorylation and Attenuates Neuronal Apoptosis in Subarachnoid Hemorrhage Rats

Aneurysmal subarachnoid hemorrhage (SAH) is a devastating emergent event associated with high mortality and morbidity. Survivors usually experience functional neurological sequelae caused by vasospasm-related delayed ischemia. In this study, male Sprague-Dawley rats were randomly assigned to five gr...

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Bibliographic Details
Main Authors: Chieh-Hsin Wu, Yi-Cheng Tsai, Tai-Hsin Tsai, Keng-Liang Kuo, Yu-Feng Su, Chih-Hui Chang, Chih-Lung Lin
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
apoptosis
Akt
endothelial nitric oxide synthase (eNOs)
ERK
subarachnoid hemorrhage (SAH)
valproic acid (VPA)
Online Access:https://www.mdpi.com/1422-0067/22/11/5975

Internet

https://www.mdpi.com/1422-0067/22/11/5975

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