ATP-induced asymmetric pre-protein folding as a driver of protein translocation through the Sec machinery

ATP-induced asymmetric pre-protein folding as a driver of protein translocation through the Sec machinery

Transport of proteins across membranes is a fundamental process, achieved in every cell by the ‘Sec’ translocon. In prokaryotes, SecYEG associates with the motor ATPase SecA to carry out translocation for pre-protein secretion. Previously, we proposed a Brownian ratchet model for transport, whereby...

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Bibliographic Details
Main Authors: Robin A Corey, Zainab Ahdash, Anokhi Shah, Euan Pyle, William J Allen, Tomas Fessl, Janet E Lovett, Argyris Politis, Ian Collinson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-01-01
Series:eLife
Subjects:
SecA
SecYEG
protein translocation
molecular dynamics
hydrogen deuterium exchange (HDX) mass spectrometry
electron paramagnetic resonance (EPR) spectroscopy
Online Access:https://elifesciences.org/articles/41803

Internet

https://elifesciences.org/articles/41803

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