TRPV4 promotes acoustic wave-mediated BBB opening via Ca2+/PKC-δ pathway

TRPV4 promotes acoustic wave-mediated BBB opening via Ca2+/PKC-δ pathway

Introduction: Numerous studies have shown the ability of low-energy acoustic waves such as focused ultrasound or shockwave to transiently open blood-brain barrier (BBB) and facilitate drug delivery to the brain. Preclinical and clinical evidences have well demonstrated the efficacy and safety in tre...

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Bibliographic Details
Main Authors: Wei-Hao Liao, Ming-Yen Hsiao, Yi Kung, Hao-Li Liu, Jean-Christophe Béra, Claude Inserra, Wen-Shiang Chen
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Journal of Advanced Research
Subjects:
Blood–brain barrier
Acoustic waves
Shockwave
Ultrasound
TRPV4
PKC-δ
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123220301211

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http://www.sciencedirect.com/science/article/pii/S2090123220301211

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