Hypoxic hUCMSC-derived extracellular vesicles attenuate allergic airway inflammation and airway remodeling in chronic asthma mice

Hypoxic hUCMSC-derived extracellular vesicles attenuate allergic airway inflammation and airway remodeling in chronic asthma mice

Abstract Background As one of the main functional forms of mesenchymal stem cells (MSCs), MSC-derived extracellular vesicles (MSC-EVs) have shown an alternative therapeutic option in experimental models of allergic asthma. Oxygen concentration plays an important role in the self-renewal, proliferati...

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Bibliographic Details
Main Authors: Liyang Dong, Ying Wang, Tingting Zheng, Yanan Pu, Yongbin Ma, Xin Qi, Wenzhe Zhang, Fei Xue, Zirui Shan, Jiameng Liu, Xuefeng Wang, Chaoming Mao
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Stem Cell Research & Therapy
Subjects:
Hypoxia
Human umbilical cord mesenchymal stem cells
Extracellular vesicles
Lung injury
Asthma
Online Access:https://doi.org/10.1186/s13287-020-02072-0

Internet

https://doi.org/10.1186/s13287-020-02072-0

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