RNA Is a Double-Edged Sword in ALS Pathogenesis

Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease that affects upper and lower motor neurons. Familial ALS accounts for a small subset of cases (<10–15%) and is caused by dominant mutations in one of more than 10 known genes. Multiple genes have been cau...

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Bibliographic Details
Main Authors: Benjamin L. Zaepfel, Jeffrey D. Rothstein
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
FTD
FUS
RNA
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.708181/full